Their debut EP “Farewell Forest,” was released on Brooklyn label The Social Registry in 2006.

That year Busy and Melissa moved into a warehouse in Bushwick, where they created a home studio and live rehearsal space and continued to improvise with vocals and instruments, while honing their programming and digital production skills and exploring their mutual love for hip hop music, UK garage, dubstep, and all that was rhythmically syncopated. 2007's Sinister Militia, Telepathe’s next EP on The Social Registry, included remixes by !!!’s Tyler Pope and Matmos’s Drew Daniel, which set the tone for the heavier bass and layered production that would characterize the group’s evolving sound.

In 2007, Telepathe fan Dave Sitek of TV on the Radio reached out to Busy and Melissa to offer them a month of studio time to make a full-length album under his production. The duo's home recordings from the previous year were the foundation for the critically acclaimed Dance Mother album produced by Sitek and released in the US on IAMSOUND early in 2009. Building off love for the album’s singles “Devil’s Trident” (2008) and “Chromes On It” (2009), the band hit the road following Dance Mother’s release, supporting Julian Casablancas and Diplo before headlining their own world tour. Gangnes and Livaudais, who have produced remixes for TV on the Radio, Planningtorock and others, took a break from both touring and the Brooklyn winter at the end of 2010 to begin work on their sophomore album in Busy’s hometown of Los Angeles. The pair returned to LA the following summer, where they recorded Destroyer in Echo Park with the help of Lewis Pesacov. Inspired by the California Sci-Fi of Philip K. Dick, Destroyer continues Telepathe’s experiments with complex rhythms and layered vocals.

Dave Sitek mixed Destroyer and released it in October 2012 as the first single for his new Federal Prism label, with a b-side remix by Trent Reznor of Nine Inch Nails.