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Life Itself hits theaters Sept. 21.

Dan Fogelman has been quite busy these last two years making you well up with tears and marvel at the fragility and majesty of life, love, and family with his NBC drama This Is Us. You probably should brace yourself for that to happen on a much bigger screen this fall, too.

On Tuesday, Amazon dropped the first full trailer for Life Itself, which Fogelman (Crazy, Stupid, Love) wrote and directed. The film chronicles the journey of a New York couple — played by Oscar Isaac and Olivia Wilde — who transform from college sweethearts to newlyweds to new parents. The “multigenerational saga,” which is set in New York City and Carmona, Spain, boasts a cast that includes Antonio Banderas, Annette Bening, Olivia Cooke, Sergio Peris-Mencheta, Laia Costa, Alex Monner, and Mandy Patinkin.

 

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